41 research outputs found
Bayesian analysis of exoplanet and binary orbits
We introduce BASE (Bayesian astrometric and spectroscopic exoplanet detection
and characterisation tool), a novel program for the combined or separate
Bayesian analysis of astrometric and radial-velocity measurements of potential
exoplanet hosts and binary stars. The capabilities of BASE are demonstrated
using all publicly available data of the binary Mizar A.Comment: Accepted for publication in Astronomy & Astrophysic
The barycentric motion of exoplanet host stars: tests of solar spin-orbit coupling
Empirical evidence suggests a tantalising but unproven link between various
indicators of solar activity and the barycentric motion of the Sun. The latter
is exemplified by transitions between regular and more disordered motion
modulated by the motions of the giant planets, and rare periods of retrograde
motion with negative orbital angular momentum. An examination of the
barycentric motion of exoplanet host stars, and their stellar activity cycles,
has the potential of proving or disproving the Sun's motion as an underlying
factor in the complex patterns of short- and long-term solar variability
indices, by establishing whether such correlations exist in other planetary
systems. A variety of complex patterns of barycentric motions of exoplanet host
stars is demonstrated, depending on the number, masses and orbits of the
planets. Each of the behavioural types proposed to correlate with solar
activity are also evident in exoplanet host stars: repetitive patterns
influenced by massive multiple planets, epochs of rapid change in orbital
angular momentum, and intervals of negative orbital angular momentum. The study
provides the basis for independent investigations of the widely-studied but
unproven suggestion that the Sun's motion is somehow linked to various
indicators of solar activity. We show that, because of the nature of their
barycentric motions, the host stars HD168443 and HD74156 offer particularly
powerful tests of this hypothesis.Comment: 7 pages, 3 figures. Accepted for publication in A&
The ESPRI project: astrometric exoplanet search with PRIMA I. Instrument description and performance of first light observations
The ESPRI project relies on the astrometric capabilities offered by the PRIMA
facility of the Very Large Telescope Interferometer for the discovery and study
of planetary systems. Our survey consists of obtaining high-precision
astrometry for a large sample of stars over several years and to detect their
barycentric motions due to orbiting planets. We present the operation
principle, the instrument's implementation, and the results of a first series
of test observations. A comprehensive overview of the instrument infrastructure
is given and the observation strategy for dual-field relative astrometry is
presented. The differential delay lines, a key component of the PRIMA facility
which was delivered by the ESPRI consortium, are described and their
performance within the facility is discussed. Observations of bright visual
binaries are used to test the observation procedures and to establish the
instrument's astrometric precision and accuracy. The data reduction strategy
for astrometry and the necessary corrections to the raw data are presented.
Adaptive optics observations with NACO are used as an independent verification
of PRIMA astrometric observations. The PRIMA facility was used to carry out
tests of astrometric observations. The astrometric performance in terms of
precision is limited by the atmospheric turbulence at a level close to the
theoretical expectations and a precision of 30 micro-arcseconds was achieved.
In contrast, the astrometric accuracy is insufficient for the goals of the
ESPRI project and is currently limited by systematic errors that originate in
the part of the interferometer beamtrain which is not monitored by the internal
metrology system. Our observations led to the definition of corrective actions
required to make the facility ready for carrying out the ESPRI search for
extrasolar planets.Comment: 32 pages, 39 figures, Accepted for publication in Astronomy and
Astrophysic
Metabolite ratios as potential biomarkers for type 2 diabetes:a DIRECT study
Aims/hypothesis
Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation. We then investigated if the identified metabolite ratios were associated with measures of OGTT-derived beta cell function and with prevalent and incident type 2 diabetes.
Methods
We measured the levels of 188 metabolites in plasma samples from 130 healthy members of twin families (from the Netherlands Twin Register) at five time points during a modified 3 h hyperglycaemic clamp with glucose, GLP-1 and arginine stimulation. We validated our results in cohorts with OGTT data (n = 340) and epidemiological case–control studies of prevalent (n = 4925) and incident (n = 4277) diabetes. The data were analysed using regression models with adjustment for potential confounders.
Results
There were dynamic changes in metabolite levels in response to the different secretagogues. Furthermore, several fasting pairwise metabolite ratios were associated with one or multiple clamp-derived measures of insulin secretion (all p
Conclusion/interpretation
In this study we have shown that the Val_PC ae C32:2 metabolite ratio is associated with an increased risk of type 2 diabetes and measures of insulin secretion and resistance. The observed effects were stronger than that of the individual metabolites and independent of known risk factors.</p
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a “candidate interactome” (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease pathogenesis) analysis of genome-wide association data in multiple sclerosis. We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. Interactomes were either obtained from the literature or were manually curated. The P values of all single nucleotide polymorphism mapping to a given interactome were obtained from the last genome-wide association study of the International Multiple Sclerosis Genetics Consortium & the Wellcome Trust Case Control Consortium, 2. The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. However, in line with recent data on the coexistence of common and unique strategies used by viruses to perturb the human molecular system, also other viruses have a similar potential, though probably less relevant in epidemiological terms
A “Candidate-Interactome” Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a "candidate interactome" (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease pathogenesis) analysis of genome-wide association data in multiple sclerosis. We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. Interactomes were either obtained from the literature or were manually curated. The P values of all single nucleotide polymorphism mapping to a given interactome were obtained from the last genome-wide association study of the International Multiple Sclerosis Genetics Consortium & the Wellcome Trust Case Control Consortium, 2. The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. However, in line with recent data on the coexistence of common and unique strategies used by viruses to perturb the human molecular system, also other viruses have a similar potential, though probably less relevant in epidemiological terms
Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy
Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme